The doctors to treat the menopausal symptoms often prescribe the estrogen therapy. The therapy does not necessarily contain progestogen (progesterone and progestin). It has been effectively evaluated and has been found to be the effective therapy for the vasomotor symptoms. Research has shown that opting oral, vaginal or transdermal therapy reduces the symptoms especially hot flushes by 65 to 90 percent. The research has however do not suggest that different types of estrogen actually affect the efficiency of the treatment. |
Estrogen is a steroid hormone that is basically derived from the androgenic precursons known as the androstenedione and testosterone with a process called aromatization for the estrogen therapy in Charlotte. In order of strength of the hormone, the natural occurring estrogens are known as estriol (E3), estrone (E1) and 17 beta-estradiol (E2). Their manufacturing process and various actions are complex. In this article, we are summarizing the different forms of estrogen and their functionality:
• Estriol: This is the form of estrogen that the placenta secrets during pregnancy. Other than this, it is also the peripheral metabolite of estrodiol and estrone. This is not secreted by the ovary.
• Estradiol: This hormone is secreted by the theca and granulosa cells in the ovary. This is the most predominant form of estrogen found in the premenopausal women.
• Estrone: This is formed from estrodiol in a reversible reaction, forming the most predominant circulating estrogen after menopause. It is also the byproduct of the peripheral conversion of androstenedione that is secreted by the adrenal cortex.
Decreasing amount of estrogen does not cause the menopausal symptoms. It has been prescribed with progesterone to manage the symptoms of menopause. It has been found to relieve the patient of the different symptoms of menopause and prevents various cardio vascular diseases. The therapy has also been found to remove the risk of osteoporosis. There are medical practitioners who suggest that the term “hormone replacement therapy” be converted to “hormone therapy” as it would then reflect the new shift in replacing hormones and using the same for symptomatic relief.
Several preparations are available for the hormone therapy. This would include the estrogen therapy in Charlotte or the one wherein the estrogen is used in combination with progesterone (EPT). If the estrogen increases, there is an increased chance of endometrial carcinoma and endometrial hyperplasia. Sometimes prolonged doses also increase the risk of cancer.
When this side effect of duration of use was analyzed it was found that the relative risk ranged from 2.8 for 1.5 years of use to a drastic 9.5 for more than ten years of use. This gave birth to the importance of adding progestogen especially for women with a uterus. It acts as an endometrial protection. It is forms an exception when a low dose of estrogen is administered to treat vaginal atrophy. However, there are no available data regarding the use of unopposed, low dose estrogen therapy.
There are preparations of estrogen therapy that would include oral, transdermal, vaginal formulations. With the potential risks associated with the high dose of oral regimens, the low-dose preparations are more famous. They also have specific delivery systems like the transdermal patches, gels and lotions. There are preparations that deliver systemic does of estradiol.
The estrogen affects many organs in the body that would include the liver, bone, breast, uterus, skin, breast, central nervous system and vasculature. These effects would become extreme during the times of estrogen deficiency such as in menopausal transition.
Author Bio: The author thinks that before availing estrogen therapy Charlotte, the customer should consult a doctor and then begin with the treatment. To know more about their services, visit signaturewellness.org
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